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Localization of the invadopodia-related proteins actinin-1 and cortactin to matrix-contact-side cytoplasm of cancer cells in surgically resected lung adenocarcinomas.
Hirooka S, Akashi T, Ando N, Suzuki Y, Ishida N, Kurata M, Takizawa T, Kayamori K, Sakamoto K, Fujiwara N, Kojima M, Eishi Y. Hirooka S, et al. Pathobiology. 2011;78(1):10-23. doi: 10.1159/000322734. Epub 2011 Apr 5. Pathobiology. 2011. PMID: 21474972 Free article.
METHODS: Invadopodia-related proteins, actinin-1 and cortactin, were immunohistochemically examined in 90 cases of lung adenocarcinomas. Expression of invadopodia-associated proteins and their possible regulators in lung adenocarcinomas were examined by real-time RT …
METHODS: Invadopodia-related proteins, actinin-1 and cortactin, were immunohistochemically examined in 90 cases of lung adenocarcinom …
The MEK/ERK Module Is Reprogrammed in Remodeling Adult Cardiomyocytes.
Kubin T, Cetinkaya A, Kubin N, Bramlage P, Sen-Hild B, Gajawada P, Akintürk H, Schönburg M, Schaper W, Choi YH, Barancik M, Richter M. Kubin T, et al. Int J Mol Sci. 2020 Sep 1;21(17):6348. doi: 10.3390/ijms21176348. Int J Mol Sci. 2020. PMID: 32882982 Free PMC article.
Fetal remodeling was induced through endothelial morphogens and monitored by the reexpression of Acta2, Actn1, and Actb. Serum-induced hypertrophy was determined by increased surface size and protein content of cardiomyocytes. ...
Fetal remodeling was induced through endothelial morphogens and monitored by the reexpression of Acta2, Actn1, and Actb. Serum-induce …
α-actinin-4 is essential for maintaining the spreading, motility and contractility of fibroblasts.
Shao H, Wang JH, Pollak MR, Wells A. Shao H, et al. PLoS One. 2010 Nov 11;5(11):e13921. doi: 10.1371/journal.pone.0013921. PLoS One. 2010. PMID: 21085685 Free PMC article.
Most non-muscle cells such as fibroblasts express two isoforms, alpha-actinin-1 (ACTN1) and alpha-actinin-4 (ACTN4). The high homology between these two isoforms would suggest redundancy of their function, but recent studies have suggested different regulatory roles. ...Re …
Most non-muscle cells such as fibroblasts express two isoforms, alpha-actinin-1 (ACTN1) and alpha-actinin-4 (ACTN4). The high homolog …
[Bioinformatics analysis of severe emphysema genome microarray based on GEO database].
Qin JY, Jia HZ, Zhang Y, Li DD, Shen YC, Chen L, Wen FQ. Qin JY, et al. Zhonghua Yi Xue Za Zhi. 2020 Jan 14;100(2):104-109. doi: 10.3760/cma.j.issn.0376-2491.2020.02.005. Zhonghua Yi Xue Za Zhi. 2020. PMID: 31937048 Chinese.
Objective: To investigate differential genes (DEGs) between no/mild and severe emphysema by bioinformatics analysis. Methods: The microarray dataset GSE1650, of lung tissue in no/mild and severe emphysema, was downloaded from the GEO database, and DEGs were obtained by t t …
Objective: To investigate differential genes (DEGs) between no/mild and severe emphysema by bioinformatics analysis. Methods: The microarray …
Inferring genome-wide functional modulatory network: a case study on NF-κB/RelA transcription factor.
Li X, Zhu M, Brasier AR, Kudlicki AS. Li X, et al. J Comput Biol. 2015 Apr;22(4):300-12. doi: 10.1089/cmb.2014.0299. J Comput Biol. 2015. PMID: 25844669 Free PMC article.
The modulatory networks of NF-kappaB/RelA in the context epithelial-mesenchymal transition (EMT) and burn injury have different modulators, including those involved in extracellular matrix (FBN1), cytoskeletal regulation (ACTN1), and metastasis-associated lung adeno …
The modulatory networks of NF-kappaB/RelA in the context epithelial-mesenchymal transition (EMT) and burn injury have different modulators, …
Proteomic profiling of bronchoalveolar lavage fluid in critically ill patients with ventilator-associated pneumonia.
Nguyen EV, Gharib SA, Palazzo SJ, Chow YH, Goodlett DR, Schnapp LM. Nguyen EV, et al. PLoS One. 2013;8(3):e58782. doi: 10.1371/journal.pone.0058782. Epub 2013 Mar 7. PLoS One. 2013. PMID: 23505561 Free PMC article.
RATIONALE: Ventilator-associated pneumonia (VAP) is a common complication in patients with acute lung injury (ALI) and can lead to increased morbidity and mortality. ...We identified and validated a limited proteomic signature that discriminated VAP(+) from VAP(-) patients …
RATIONALE: Ventilator-associated pneumonia (VAP) is a common complication in patients with acute lung injury (ALI) and can lead to in …
Genome-wide Association Study of Platelet Count Identifies Ancestry-Specific Loci in Hispanic/Latino Americans.
Schick UM, Jain D, Hodonsky CJ, Morrison JV, Davis JP, Brown L, Sofer T, Conomos MP, Schurmann C, McHugh CP, Nelson SC, Vadlamudi S, Stilp A, Plantinga A, Baier L, Bien SA, Gogarten SM, Laurie CA, Taylor KD, Liu Y, Auer PL, Franceschini N, Szpiro A, Rice K, Kerr KF, Rotter JI, Hanson RL, Papanicolaou G, Rich SS, Loos RJ, Browning BL, Browning SR, Weir BS, Laurie CC, Mohlke KL, North KE, Thornton TA, Reiner AP. Schick UM, et al. Am J Hum Genet. 2016 Feb 4;98(2):229-42. doi: 10.1016/j.ajhg.2015.12.003. Epub 2016 Jan 21. Am J Hum Genet. 2016. PMID: 26805783 Free PMC article.
We performed a genome-wide association study of platelet count in 12,491 participants of the Hispanic Community Health Study/Study of Latinos by using a mixed-model method that accounts for admixture and family relationships. We discovered and replicated associations with five ge …
We performed a genome-wide association study of platelet count in 12,491 participants of the Hispanic Community Health Study/Study of Latino …